Tawaun A. Lucas

Tawaun A. Lucas

Senior Scientist, Translational Data Science

Calico Life Sciences

About me

Hello, I’m Dr. Tawaun A. Lucas, a computational biologist with a Ph.D. in Neuroscience from Stanford University. I’m currently a Senior Scientist in Translational Data Science at Calico Life Sciences in South San Francisco, CA, where I lead single-cell meta-analyses of glial stress across Parkinson’s, Alzheimer’s, and multiple sclerosis cohorts to identify biomarkers, define patient subgroups, and evaluate therapeutic targets. My work applies AI/ML and scalable computational workflows to single-cell and spatial multi-omic data in neurodegeneration and immunology, and I partner closely with wet-lab scientists to carry computational findings into experimental validation. Previously, I built and benchmarked AI tools for single-cell and spatial analysis at LatchBio and Biohub (formerly the Chan Zuckerberg Initiative), and at Genentech I created a cross-disease atlas of human and mouse astrocytes and led the development of spatial transcriptomics pipelines.

With a strong foundation in both research and education, I have a proven track record of cross-functional collaboration and impactful contributions to the scientific community. Explore my site to learn more about my research, publications, and professional journey.

Download my CV

Education
  • Ph.D. in Neuroscience, 2021

    Stanford University

  • Bachelor's Psychology (Honor's), 2014

    California State University, Northridge

Interests
  • Bioinformatics
  • Neuroscience/Neuroimmunology
  • Neurodegeneration

Publications & Preprints

Hereditary spastic paraplegia (HSP) gene 11 (Spg11) attenuates lipid accumulation in myeloid cells and neuroinflammation in the midbrain without affecting α-synuclein pathology
SpatialAgent - An autonomous AI agent for spatial biology